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POLY(ADP-RIBOSE) POLYMERASES
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DeCS
Descriptor
English
:
Poly(ADP-ribose) Polymerases
Descriptor
Spanish
:
Poli(ADP-Ribosa) Polimerasas
Descriptor
Portuguese
:
Poli(ADP-Ribose) Polimerases
Synonyms
English
:
ADP-Ribosyltransferase (Polymerizing)
Poly(ADP-ribose) Polymerase
Poly(ADP-Ribose) Synthase
Poly ADP Ribose Polymerase
Tree Number:
D08.811.913.400.725.115.690
Definition
English
:
Enzymes
that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e.,
POLY ADENOSINE DIPHOSPHATE RIBOSE.
Entry Combination - descr/qualif
English
:
Poly(ADP-ribose) Polymerases
/
antagonists & inhibitors
use
Poly(ADP-ribose) Polymerase Inhibitors
History Note
English
:
2003 (1977); use NAD NUCLEOSIDASE 1975-1976
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30405
Unique Identifier:
D011065
Occurrence in VHL
:
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CID-10
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